|
Entry | R1R2 | Solvent | In(OTf)3MSTFA | Time (h) | Yielda (%) |
| 1 | MeH | toluene | 10 mol%3.5 eq | 3 | 70 |
| 2 | MeH | toluene | 5 mol%3.5 eq | 3 | 70 |
| 3 | MeH | toluene | 5 mol%2.5 eq | 3 | 63 |
| 4 | MeH | toluene | 5 mol%1.5 eq | 3 | 32 |
| 5 | MeH | THF | 5 mol%3.5 eq | 3 | 42 |
| 6 | HOMe | toluene | 5 mol%3.5 eq | 3 | quant |
| 7 | HOMe | THF | 5 mol%3.5 eq | 3 | 65 |
| 8 | HCl | toluene | 5 mol%3.5 eq | 3 | quant |
| 9 | HCl | THF | 5 mol%3.5 eq | 3 | 39 |
